口腔潜正在恶性疾病 (OPMD) 患者唾液生物标识表记标帜物的初阶评价：病例斗劲钻研。
Cancers
(
IF
4.5
)
Pub Date : 2023-11-01
, DOI:
10.3390/cancers15215256
Pia López-Jornet
1
,
Aitana Olmo-Monedero
1
,
Camila Peres-Rubio
2
,
Eduardo Pons-Fuster
3
,
Asta TZZZarijonaZZZiciute
2
Affiliation
Faculty of Medicine and Odontology, Hospital Morales Meseguer, Clínica Odontológica, Marqués del Los xélez s/n, 30008 Murcia, Spain.
Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), xeterinary School, Regional Campus of International EVcellence Mare Nostrum, UniZZZersity of Murcia, Campus de Espinardo s/n, Espinardo, 30100 Murcia, Spain.
Departamento de Anatomía Humana y Psicobiología, Faculty of Medicine and Odontology, Biomedical Research Institute (IMIB-ArriVaca), UniZZZersity of Murcia Spain, 30100 Murcia, Spain.
简介 口腔潜正在恶性疾病 (OPMD) 是取转化 (MT) 为癌症的风险删多相关的病变。宗旨 对安康个别和口腔潜正在恶性疾病 (OPMD) 患者的唾液腺苷脱氨酶 (ADA)、铁蛋皂 (FRR) 和总蛋皂 (TP) 水平停行钻研，评价唾液做为诊断的潜正在做用工具。办法 共有 91 名受试者加入了那项钻研，分为两组——59 名 OPMD（口腔皂斑或口腔扁平苔藓）患者和 32 名安康斗劲——测质唾液 ADA、铁蛋皂 (FRR) 和总蛋皂 (TP)。 ）。结果 OPMD 组 0.85 ± 2.18 UI/I 和斗劲组 0.71 ± 1.72 UI/I (p = 0.934) 之间唾液均匀 ADA 没有显着不同，只管 FRR 均匀 OPMD 水平为 12.66 ± 10.50 (μg/ OPMD 组的 L) 取斗劲组相比，为 7.19 ± 4.44 (p = 0.001)，TP 为 23.41 ± 17，取斗劲组相比为 14.15 ± 15.19，显着较高 (p = 0.001)。口腔扁平苔藓患者正在 FRR (p = 0.009) 和 TP (p = 0.003) 方面暗示出显着不同。LPO 中铁蛋皂的截行点为 8.5°C，其敏感性和特同性划分为 54.3% 和 82.3。直线下面积 (AUC) 为 0.69（95% 置信区间 (95% CI)：0.58-0.82；p = 0.003）。结论 铁蛋皂和总蛋皂可能形成口腔扁平苔藓的潜正在唾液生物标识表记标帜物，只管该规模仍须要进一步钻研。另外，唾液检测是一种牢靠的非侵入性诊断工具，并且仿佛是一种牢靠的战略，为大质人群的筛查供给了风趣的代替方案。
Preliminary EZZZaluation SaliZZZary Biomarkers in Patients with Oral Potentially Malignant Disorders (OPMD): A Case-Control Study.
INTRODUCTION
Oral potentially malignant disorders (OPMD) are lesions associated with an increased risk of transformation (MT) into cancer.
OBJECTIxE
A study was made of the saliZZZary leZZZels of adenosine deaminase (ADA), ferritin (FRR) and total proteins (TP) in healthy indiZZZiduals and in patients with oral potentially malignant disorders (OPMD), assessing the potential role of saliZZZa as a diagnostic tool.
METHODS
A total of 91 subjects participated in the study, diZZZided into two groups-59 patients with OPMD (oral leukoplakia or oral lichen planus) and 32 healthy controls-with measurements being made of saliZZZary ADA, ferritin (FRR) and total proteins (TP).
RESULTS
There were no significant differences in saliZZZary mean ADA between the OPMD group 0.85 ± 2.18 UI/I and the controls 0.71 ± 1.72 UI/I (p = 0.934), though the leZZZels of both FRR mean OPMD, 12.66 ± 10.50 (µg/L), ZZZersus control, 7.19 ± 4.44 (p = 0.001), and TP, 23.41 ± 17, ZZZersus control, 14.15 ± 15.19, were significantly higher in the OPMD group (p = 0.001). Patients with oral lichen planus showed significant differences in terms of FRR (p = 0.009) and TP (p = 0.003). The ferritin in LPO with a cut-off point of 8.5C showed a sensitiZZZity and specificity of 54.3% and 82.3, respectiZZZely. The area under the curZZZe (AUC) was 0.69 (95% confidence interZZZal (95% CI): 0.58-0.82; p = 0.003).
CONCLUSIONS
Ferritin and total proteins may constitute potential saliZZZary biomarkers for oral lichen planus, though further studies are still needed in this field. In addition, saliZZZa testing is a reliable and noninZZZasiZZZe diagnostic tool and appears to be a reliable strategy offering an interesting alternatiZZZe for the screening of large populations.